Clinical and molecular characteristics of NF1 mutant lung cancer

Autor:	Pasi A. Jänne, Amanda J. Redig, Caitlin Fontes, Suzanne E. Dahlberg, Stacy L. Mach, Yunling Shi, Poornima Chalasani, Marzia Capelletti
Rok vydání:	2015
Předmět:	congenital hereditary and neonatal diseases and abnormalities Cancer Research Mutant Biology medicine.disease Molecular biology eye diseases nervous system diseases law.invention Oncology law Cancer research medicine Suppressor Map kinase signaling Lung cancer neoplasms
Zdroj:	Journal of Clinical Oncology. 33:8022-8022
ISSN:	1527-7755 0732-183X
Popis:	8022 Background: NF1 is a tumor suppressor that negatively regulates Ras, thus NF1 mutant tumors may also be sensitive to inhibitors of MAP kinase signaling. NF1 variants occur in lung cancer, but ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05ec4cff397b9acafdef2a387643b84b https://doi.org/10.1200/jco.2015.33.15_suppl.8022 Zobrazit plný text záznamu