Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties

Autor:	Shiwu Dong, Hong Li, Sheng-Lin Luo, Zhangyou Yang, Rong Li, Xiaochao Yang, Hong Jiang, Jian He
Rok vydání:	2014
Předmět:	Surface coating Functional importance Chemistry General Chemical Engineering Blood circulation Biological property Biophysics Nanoparticle Nanotechnology General Chemistry Cytotoxicity
Zdroj:	RSC Adv.. 4:59965-59969
ISSN:	2046-2069
Popis:	The bisphosphonate group of alendronate was found to possess high binding affinity to ceria nanoparticles (CNPs). Using alendronate as an anchor, functional molecules could be easily grafted onto CNPs leading to enhanced enzyme mimetic activity, reduced cytotoxicity, improved stability, prolonged blood circulation, and decreased liver and especially spleen accumulation of the nanoparticles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05e95b99c797be4733f2245acc39a9cd https://doi.org/10.1039/c4ra12007h Zobrazit plný text záznamu