Evolutionary conservation of ‘Basket’ structure in nuclear pore complexes, and their possible role in mRNA export
| Autor: | M. W. Goldberg, I. Solovei, C. Pelling, T. D. Allen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 52:12-13 |
| ISSN: | 2690-1315 0424-8201 |
| DOI: | 10.1017/s0424820100167792 |
| Popis: | The nuclear pore complex (NPC) is a macromolecular complex which provides transport through the nuclear envelope. Each NPC has a diameter of around 120 nms, and extends outwards into the cytoplasm by some 20 nms via eight cytoplasmic filaments of granular substructure. On the nucleoplasmic face, NPC ‘cages’ or ‘baskets’ project some 60 nms into the nuclear interior where they terminate in an inner basket ring that supports a further structure, the nuclear envelope lattice (NEL), a network of filaments. Both the NEL and NPC baskets have been visualised to date only in amphibian germinal vesicle nuclear envelopes. All current models of NPC structure are based on data from amphibian oocytes, mainly due to the convenience of isolating clean and well preserved nuclear envelopes. It is important therefore to determine how widely these structures are conserved in other groups throughout the animal kingdom, as a basis for the overall evolutionary conservation of NPC structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|