Hepatotoksyczność leków stosowanych u noworodków

Autor:	Maria K Kornacka, Maria Wilińska
Rok vydání:	2014
Předmět:	medicine.medical_specialty business.industry Bioinformatics Hepatic toxicity Structure and function chemistry.chemical_compound Endocrinology chemistry Biotransformation Internal medicine Pediatrics Perinatology and Child Health medicine Xenobiotic business
Zdroj:	Pediatria Polska. 89:185-191
ISSN:	0031-3939
DOI:	10.1016/j.pepo.2014.03.007
Popis:	Liver's development process includes growth and maturing. These changes in the structure and function have a major impact on the way drugs and other xenobiotics undergo the processes of biotransformation. Medications and their metabolic products may be toxic to the liver as well as other organs of the body. This article is a review of knowledge about the development of liver, dynamic changes in its structure and function and hepatic toxicity of xenobiotics. Particular attention was paid to reviewing substances toxic for the newborn. It was considered necessary to take into account aspects of the anatomical, physiological and developmental susceptibility of liver to xenobiotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05e066a72825dea8c7f9b4f3362a03ad https://doi.org/10.1016/j.pepo.2014.03.007 Zobrazit plný text záznamu