Telomere shortening and frailty in Mexican older adults
| Autor: | Mauricio Ortiz-Ramírez, Haydeé Rosas-Vargas, Sergio Sánchez-García, Elba Reyes-Maldonado, Paola García-Dela Torre, Rosalinda Sánchez-Arenas |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gerontology education.field_of_study business.industry Population Frail Older Adults Frailty syndrome medicine.disease Telomere 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Mexico city Medicine Functional decline business education Clinical syndrome Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Geriatrics & Gerontology International. 18:1286-1292 |
| ISSN: | 1444-1586 |
| Popis: | AIM Telomere shortening has been associated with several age-related diseases, in addition to being considered a hallmark of aging. Frailty is a clinical syndrome characterized by an accentuated physiological and functional decline that might be a predictor of an adverse condition in older age. The present study evaluated the relationship between frailty and telomere shortening in older adults from Mexico City, Mexico. METHODS This was a cross-sectional study. Data were collected from 323 frail older adults, including physical and environmental factors, such as body mass index, comorbidities, physical activity and tobacco consumption. Telomere length was measured by real-time polymerase chain reaction. The frailty syndrome was diagnosed using the Fried criteria. RESULTS An association between frailty and telomere shortening was found in both sexes. Telomere length decreased from 6.05 kb (5.54-6.48 kb) to 4.20 kb (3.80-4.54 kb; P |
| Databáze: | OpenAIRE |
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