New Iridoids from the Whole Plant of Patrinia heterophylla
| Autor: | Ping Liu, Li-Hua Mu, Yu-Ning Wang, Li Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Iridoid Traditional medicine 010405 organic chemistry Chemistry medicine.drug_class Patrinia heterophylla Flavonoid Positive control Plant Science General Chemistry 01 natural sciences Jurkat cells General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine Cytotoxic T cell Two-dimensional nuclear magnetic resonance spectroscopy K562 cells |
| Zdroj: | Chemistry of Natural Compounds. 55:32-35 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-019-02609-7 |
| Popis: | Two new iridoids (1, 2), along with one known iridoid (3), two known triterpenoid saponins (4, 5), and one known flavonoid (6), were isolated from the whole plant of Patrinia heterophylla Bunge. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially by means of 1D and 2D NMR and HR-ESI-MS analyses. The cytotoxic activity of the isolated compounds against human leukemic cells was evaluated using CCK-8 assay. Compounds 1 and 2 showed cytotoxic activities against HL-60, K562, and Jurkat cells, and compounds 3 and 5 showed cytotoxic activity against HL-60. Among them, compound 1 showed slightly stronger cytotoxic activity against K562 cells than the positive control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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