Non-invasive assessment of endothelial function of systemic arteries during obstructive chronic bronchopneumopathy in African Black subjects
| Autor: | Mor Diaw, Abdou Khadir Sow, Mbaye Sene, Modou Oumy Kane, Abdoulaye Samb, A. Mbengue, Valentin Ouedraogo, Abdoulaye Ba, Diaty Sow, Fatou Bintou Sar, Maimouna Toure, Mamadou Sarr, Arnaud Jf. Tiendrébéogo |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
COPD medicine.diagnostic_test Physiology business.industry Physical examination Disease medicine.disease Body fat percentage Internal medicine medicine Cardiology General Pharmacology Toxicology and Pharmaceutics Endothelial dysfunction Underweight medicine.symptom business Body mass index Reactive hyperemia |
| Zdroj: | National Journal of Physiology, Pharmacy and Pharmacology. 9:1 |
| ISSN: | 2320-4672 |
| DOI: | 10.5455/njppp.2019.0930210112018 |
| Popis: | Background: Chronic obstructive pulmonary disease (COPD) is characterized by high mortality. The latter is strongly attributed to cardiovascular events whose onset is endothelial dysfunction and vascular remodeling. Aims and Objectives: The aims were to evaluate the endothelial function during COPD and the factors involved with possible endothelial dysfunction in Senegalese Black men aged at least 18 years. Materials and Methods: This was a prospective and cross-sectional study. After a complete clinical examination and evaluation of the body composition by a bioimpedancemeter, the endothelial function was evaluated by EndoPAT2000®. Results: the mean age was 61.50 years ± 6.62. Of the subjects, 70% were smokers and 50% had limited chest enlargement. According to the body mass index and the percentage of body fat, underweight was 30% and 40%, respectively. The 75.5% of the meager could not be evaluated by bio-impedancemeter due to extreme thinness. Endothelial dysfunction involved 70% of subjects. In addition, 86% of subjects with endothelial dysfunction were smokers. The reactive hyperemia index was positively correlated with body mass index (P = 0.017 and r = 0.73), body fat percentage (P = 0.016 and r = 0.73) and visceral fat level (P = 0.008 and r = 0.78). Conclusion: The evolution of COPD would be laced with serious cardiovascular complications often fatal. The assessment of nutritional status and endothelial function is fundamental for better management of the disease. |
| Databáze: | OpenAIRE |
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