The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety- like behaviors in Wistar male rats

Autor:	Hatam Ahmadi, Mohammad-Reza Zarrindast, Parvin Rostami, Mohammad Nasehi
Rok vydání:	2019
Předmět:	Agonist medicine.medical_specialty medicine.drug_class business.industry Dopaminergic Nucleus accumbens Quinpirole Endocrinology Dopamine receptor Dopamine receptor D2 Internal medicine medicine NMDA receptor Sulpiride business medicine.drug
Zdroj:	Medical Journal of Tabriz University of Medical Sciences and Health Services. 41:7-13
ISSN:	2008-160X 1608-5671
Popis:	Background: Neutrustransmitter systems of dopaminergic and glutamatergic of the prefrontal cortex (PFC) and nucleus accumbens (NAc) are involved in the regulation of anxiety-like behaviors. In addition, the activity of the NAc dopaminergic system is mediated by the glutamatergic inputs, which is mainly from the PFC. This study investigated the role of D2 dopaminergic system in nucleus accumbens and glutamatergical system of prelimbic area on anxiety- like behaviors in male rats. Methods: This study was performed on four experimental groups in 35 groups of 8 male rats. after 5 days of surgery in a stereotaxic frame, the Elevated Plus maze apparatus was employed for the recording parameters of anxiety-like behaviors due to intr-abrain injection of quinpirole (Dopamine receptor agonist), sulpiride (Dopaminergic D2 receptor antagonist), NMDA(NMDA receptor agonist) and D-AP7 (NMDA receptor antagonist. Results: Unilateral intra- left prelimbic injection of NMDA (0.9 μg/μl) reduced the anxiety-like behaviors (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05d227f70578cb3425f94000b4aa24d3 https://doi.org/10.34172/mj.2019.014 Zobrazit plný text záznamu