Management of Autosomal Dominant Polycystic Kidney Disease (ADPKD) During Pregnancy: Risks and Challenges

Autor:	Lucy McBride, Catherine Wilkinson, Shilpanjali Jesudason
Rok vydání:	2020
Předmět:	Pregnancy Pediatrics medicine.medical_specialty 030219 obstetrics & reproductive medicine PKD1 medicine.diagnostic_test urogenital system business.industry Autosomal dominant polycystic kidney disease Obstetrics and Gynecology Renal function Disease urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications 03 medical and health sciences Cystic kidney disease 0302 clinical medicine Oncology Maternity and Midwifery medicine 030212 general & internal medicine Risk factor business Genetic testing
Zdroj:	International Journal of Women's Health. 12:409-422
ISSN:	1179-1411
Popis:	Autosomal dominant polycystic kidney disease (ADPKD) affects up to 1 in 1000 people. The disease is characterized by the progressive development of cysts throughout the renal parenchyma due to inherited pathogenic variants in genes including PKD1 or PKD2 and eventually leads to gradual loss of renal function, along with manifestations in other organ systems such as hepatic cysts and intracranial aneurysms. ADPKD management has advanced considerably in recent years due to genetic testing availability, pre-implantation genetic diagnosis technology and new therapeutic agents. Renal disease in pregnancy is recognised as an important risk factor for adverse maternal and fetal outcome. Women with ADPKD and health professionals face multiple challenges in optimising outcomes during the pre-pregnancy, pregnancy and post-partum periods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05bdf4254aa6a1da936cd14130dba8ac https://doi.org/10.2147/ijwh.s204997 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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