Intramolecular hydrogen bonding guides a cationic amphiphilic organocatalyst to highly stereoselective aldol reactions in water

Autor:	Ignacio Alfonso, Ciril Jimeno, Alba Catot, Ángel M. Valdivielso
Rok vydání:	2015
Předmět:	Hydrogen bond General Chemical Engineering Cationic polymerization Substrate (chemistry) General Chemistry Combinatorial chemistry chemistry.chemical_compound chemistry Aldol reaction Intramolecular force Amphiphile Organic chemistry Moiety Guanidine
Zdroj:	RSC Advances. 5:62331-62335
ISSN:	2046-2069
DOI:	10.1039/c5ra12135c
Popis:	A novel amphiphilic guanidine organocatalyst, efficient for asymmetric aldol reactions of ketones in water at neutral pH, is disclosed. The reaction presented a clear substrate dependence depicting a free energy linear correlation with ee. Intramolecular hydrogen bonding in the acylguanidine moiety was identified as the key structural motif.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05b820e469b138e69988d3fb8cef2807 https://doi.org/10.1039/c5ra12135c Zobrazit plný text záznamu