| Autor: |
Kun Li, Runming Jin, Zhong-Jian Wang, Yaqing Shen, Fen Zhou, Zhujun Wang, Xiaoyan Wu, Wenfu Xu |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.22541/au.160551193.38118284/v1 |
| Popis: |
Background: Methotrexate is safely administered to most patients but can also cause severe toxicities. It is necessary to individualize methotrexate dose to maintain suf-ficient exposure while minimizing toxicities. Procedure: We enrolled 1174 cycles of high-dose methotrexate chemotherapy from 294 patients treated following the CCCG-ALL-2015 protocol and explored risk fac-tors of toxicities, methotrexate clearance delay and relapse. We compared those who received a fixed-dose reduction (Program 1) with those who were dose-adjusted by added methotrexate concentration test at 16h (Program 2) after methotrexate clear-ance delay existed the last cycle. Results: Female, IR/HR group, BSA 6years, male and IR/HR group (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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