| Popis: |
There is extensive of literature and experimental studies on nitroxyl-labeled phosphorus compounds [1–5]. The growing interest in such radicals is explained first by the fact that phosphorus compounds have a wide spectrum of biological activity (antitumor, anticholinesterase, cholinolytic, etc). Secondly, modification of organophosphorus compounds by nitroxyl radicals can encourage the preparation of a variety of novel biologically active compounds that can be utilized as labels to study enzymes and nucleic acids [6–8], drugs [9–18], or contrast agents [19–21]. |
