Chiral discrimination in nonracemic mixtures of methanephosphonic acid,N,N?-bis(1-phenylethyl)diamides

Autor:	Mikhail I. Kadyko, É. I. Fedin, Andrei B. Ouryupin, Pavel V. Petrovskii
Rok vydání:	1994
Předmět:	Pharmacology Chemistry Organic Chemistry Catalysis Coupling reaction Analytical Chemistry NMR spectra database Phosphorus atom Drug Discovery Chemical preparation Organic chemistry Phosphorus-31 NMR spectroscopy Enantiomer Spectroscopy
Zdroj:	Chirality. 6:1-4
ISSN:	1520-636X 0899-0042
DOI:	10.1002/chir.530060103
Popis:	Enantiomeric (S,S)- and (R,R)-bis(1-phenylethyl)diamidomethylphosphonates, the phosphorus atom being prochiral, have been synthesized, starting from the methanephosphonic acid dichloride and corresponding chiral amines. The splitting observed in the 31P-NMR spectra of their nonracemic mixtures may be accounted for the self-discrimination of chiral species. This effect can be very useful for enantiomeric analysis of amines based on coupling reactions with methanephosphonic acid dichloride. © 1994 Wiley-Liss, Inc.
Databáze:	OpenAIRE
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