Chiral β-dimethylaminoalkylphosphines. Highly efficient ligands for a nickel complex catalyzed asymmetric grignard cross-coupling reaction

Autor:	Tamio Hayashi, Makoto Kumada, Mitsuo Konishi, Motoo Fukushima
Rok vydání:	1980
Předmět:	inorganic chemicals chemistry.chemical_classification Organic Chemistry chemistry.chemical_element Biochemistry Medicinal chemistry Coupling reaction Amino acid Catalysis Nickel chemistry Yield (chemistry) Drug Discovery Organic chemistry
Zdroj:	Tetrahedron Letters. 21:79-82
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)93629-3
Popis:	Chiral β-dimethylaminoalkylphosphines were prepared starting with amino acids, (S)-alanine, (S)-phenylalanine, (R)-phenylglycine, (S)-valine, and (R)-tert-leucine. The chiral phosphines were found to be highly efficient ligands for a nickel catalyzed asymmetric Grignard cross-coupling reaction (38∼94% optical yield).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::058edffe565c3e168046b1cfae5f6190 https://doi.org/10.1016/s0040-4039(00)93629-3 Zobrazit plný text záznamu