Gold‐Catalyzed Synthesis of 1,3‐Diaminopyrazoles from 1‐Alkynyltriazenes and Imines
| Autor: | Rosario Scopelliti, Kay Severin, Loïc Jeanbourquin, Farzaneh Fadaei Tirani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Imine Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Coupling reaction 0104 chemical sciences Reaction product Inorganic Chemistry chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Physical and Theoretical Chemistry Triazene |
| Zdroj: | Helvetica Chimica Acta. 100:e1700186 |
| ISSN: | 1522-2675 0018-019X |
| Popis: | A new procedure for the synthesis of highly substituted 1,3-diaminopyrazoles is described. As substrates, we have employed 1-alkynyltriazenes and imines. The formation of pyrazoles was achieved by two-fold C-N coupling reactions in the presence of (JohnPhos)AuCl and AgNTf2 as catalyst precursors. The regioselectivity of the reaction was inferred from a crystallographic analysis of one reaction product. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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