Circulatory levels of pro-inflammatory cytokines (IL-6 and IL-1β) and neutrophil-lymphocyte ratio (NLR) in diabetic patients in Nigerian population
| Autor: | Anthonia A. Okerengwo, Jonah Sydney Aprioku, Eugene E. Akujuru |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Hematology biology 040301 veterinary sciences business.industry Lymphocyte medicine.medical_treatment fungi Type 2 Diabetes Mellitus 04 agricultural and veterinary sciences medicine.disease Gastroenterology Pathology and Forensic Medicine Proinflammatory cytokine 0403 veterinary science Pathogenesis medicine.anatomical_structure Cytokine Internal medicine Diabetes mellitus medicine biology.protein Anatomy business Interleukin 6 |
| Zdroj: | Comparative Clinical Pathology. 29:539-545 |
| ISSN: | 1618-565X 1618-5641 |
| DOI: | 10.1007/s00580-019-03086-8 |
| Popis: | Inflammatory mediators like pro-inflammatory cytokines have been linked with the pathogenesis of type 2 diabetes mellitus (T2DM). Neutrophil-lymphocyte ratio (NLR) has also recently emerged as a possible reliable and cost-effective marker of diabetes. This study was designed to evaluate pro-inflammatory cytokine levels (IL-6 and IL-1β) and NLR in T2DM subjects in Nigerian population. This was a case-control study involving 75 physician diagnosed T2DM subjects attending the Endocrine Clinic of a Tertiary Health Institution in Nigeria and 75 age- and sex-matched healthy individuals (used as control) who were recruited from the Blood Donor Center of the same institution. Based on physician assessment, the diabetic subjects were grouped differently into those with complications (48) and those without complications (27). Serum levels of IL-6 and IL-1β were measured using ELISA technique, while neutrophil and lymphocyte counts were evaluated using a hematology autoanalyzer from which NLR was calculated. NLR and serum levels of IL-6 were significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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