Inversion de polarite a4 des cetones α-alleniques par le groupe triphenylphosphonio

Autor:	Henri-Jean Cristau, Jacques Viala, Henri Christol
Rok vydání:	1982
Předmět:	chemistry.chemical_classification Ketone Double bond Chemistry Stereochemistry Organic Chemistry Regioselectivity Biochemistry Umpolung Adduct chemistry.chemical_compound Methyl Ketone Drug Discovery Electrophile Methanol
Zdroj:	Tetrahedron Letters. 23:1569-1572
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)87160-9
Popis:	The a4 umpolung of α-allenic ketone sis performed using the triphenylphosphonio group. It results in inducing an electrophilic character at the carbon ψ to the carbonyl function and in changing the regioselectivity of the additions of active hydrogen compounds on the carbon-carbon double bond to give finally the adducts 4 (Fig. 1). This new umpolung method is illustrated here in the case of the addition of methanol on allenyl methyl ketone 1a (Fig. 2).
Databáze:	OpenAIRE
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