| Autor: |
Amjad Beg, Sonu Chand Thakur, Fareeda Athar |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Pharmacy & Pharmacology International Journal. 8:234-243 |
| ISSN: |
2379-6367 |
| DOI: |
10.15406/ppij.2020.08.00300 |
| Popis: |
Mycobacterium tuberculosis H Rv M tuberculosis genetic evaluation found various conditional mutants that are being unsuccessful in surviving in non permissive temperature or need enriched sources for growing in non adaptive conditions In M tuberculosis basically these mutants refer to as Filamentous Temperature Sensitive FTS gene family which have Rv c Rv c Rv c Rv c Rv c Rv c Rv c and Rv cproteins that are involved in major processes like cell division cell growth and cell signalling This manuscript provides a straightforward conduit towards finding the exact role of Rv c and Rv c genes in cellular cell divisionand survival of this bacterium by using computational approaches The physiochemical properties shows both the proteins are stable and protein protein interaction shows Rv c R c smpB Rv c and Rv c commonly interacted with each other but Rv c protein a transmembrane protein which has four transmembrane helices which provide a clue for these proteins that act in various signalling cascades and protein exporting system The protein phosphorylation play important role in several cellular processes and in Rv c phosphorylation occurs at Thr Ser and in Rv c phosphorylation occurs at residues Thr Thr Thr Ser Ser and Tyr The predicted structure was validated by SAVES metaserver and Ramachandran plot shows above residues were present in the allowed region In the prediction of B cell and T cell on Rv c and Rv c protein antigen presentation and antibody binding properties were determined These epitopes can be used to develop more effective vaccines and identify neutralizing antibodies The mutation identification on the F and F in Rv c whereas in Rv c on position F cause a drastic loss in inter atomic interactions As Rv c and Rv c proteins are essential class of proteins in M tuberculosis therefore understanding of this class is crucial for analyzing cell division mechanism of this bacterium and thus help in clarifying its pathogenesis mechanism inside the host nbsp |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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