Teratogenic Characteristics by Single Dosing of Antineoplastic Platinum Complexes in Rats
| Autor: | Yasuhiko Hasegawa, Yonetaka Fukiishi, Ri-ichi Muranaka, Hisashi Tsuiki |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
inorganic chemicals
Cisplatin Embryology medicine.medical_specialty Late stage Gestational age Organogenesis General Medicine Biology female genital diseases and pregnancy complications Surgery Limb bud Endocrinology Internal medicine Pediatrics Perinatology and Child Health medicine Gestation Dosing Craniofacial neoplasms Developmental Biology medicine.drug |
| Zdroj: | Congenital Anomalies. 35:73-86 |
| ISSN: | 1741-4520 0914-3505 |
| DOI: | 10.1111/j.1741-4520.1995.tb00301.x |
| Popis: | We investigated the embryolethality and teratogenicity of a new platinum complex, 254-S, and cisplatin (CDDP) by single dosing to dams on one day during the period of organogenesis. The results are summarized as follows: (1) Embryolethality was maximal after 254-S treatment on day 7 of gestation (Day 7) and after CDDP treatment on Days 6 to 9. It decreased with advancing gestational age. (2) Both 254-S and CDDP were teratogenic. The critical period for induction of malformation appeared twice for 254-S, at Days 6 to 9 and at Days 14 to 15, and once for CDDP, at Days 5 to 8. (3) The types of malformations induced by 254-S or CDDP were different, indicating different mode of teratogenesis. 254-S caused malformations mainly in the craniofacial or limb bud areas in the biphasic manner, whereas CDDP caused malformations mainly of the limb buds in the monophasic manner. (4) Malformations of the limb/digit and tail that are known to have critical periods during the late stage of organogenesis were induced by treatment with 254-S on Day 7 and with CDDP on Day 5 or 6. |
| Databáze: | OpenAIRE |
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