Effects of Convulsive Activity on the Subunit Composition of Ca2+/Calmodulin-Dependent Protein Kinase II in the Hippocampus of Krushinskii–Molodkina Rats
| Autor: | T. A. Savina, T. G. Shchipakina, Oleg V. Godukhin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Chemistry General Neuroscience Protein subunit Hippocampus Hippocampal formation Protein kinase II medicine.anatomical_structure Endocrinology nervous system Ca2+/calmodulin-dependent protein kinase Internal medicine medicine Composition (visual arts) Neuron Protein kinase A Neuroscience |
| Zdroj: | Neuroscience and Behavioral Physiology. 43:267-274 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-013-9727-y |
| Popis: | Experiments were performed showing that in the hippocampus of Krushinskii–Molodkina (KM) rats, which have an inherited predisposition to audiogenic seizures, the content of β (but not α) subunits of CaMKII was 40% lower than that in sound-resistant Wistar rats. At 24 h after single seizures, the subunit composition of CaMKII in the hippocampus of KM rats showed no difference from that in controls, though at 72 h, the β-CaMKII content increased by 56%. Conversely, after five and 20 seizures, the β-CaMKII level was significantly decreased at both 24 and 72 h. The hippocampal protein kinase α subunit composition in rats of these groups showed no difference. It can be suggested that these changes in the CaMKII subunit composition in the hippocampus of KM rats represent an important component of the specific homeostatic mechanism of functioning of hippocampal neurons supported their “retuning” in relation to the nature of preceding neuron activity. |
| Databáze: | OpenAIRE |
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