Characteristics of the Immunoresponse in Elderly People and Autoimmunity

Autor:	O. V. Moskalec
Rok vydání:	2020
Předmět:	business.industry Autoantibody Immunosenescence Acquired immune system medicine.disease_cause Proinflammatory cytokine Autoimmunity Immune system Immunology Elderly people Medicine Geriatrics and Gerontology business Gerontology Immunoresponse
Zdroj:	Advances in Gerontology. 10:368-376
ISSN:	2079-0589 2079-0570
DOI:	10.1134/s2079057020040153
Popis:	Aging is a highly complex process that results in the dysregulation of all systems in the human organism. The most important changes in the immune system, which are collectively known as immunosenescence, include lower levels of immunoresponse to infections, increased levels of proinflammatory mediators, and weakened control over self-reactive clones. In elderly people, immunoscenescence is usually observed along with low-grade, aseptic inflammation (inflammaging) which is considered to be associated with a higher incidence of chronic, noninfectious, age-related diseases. This paper discusses the main changes in the innate and adaptive immunity in aging and their impact on the induction of autoimmune processes and provides data on the frequency of autoantibody detection in elderly people and the clinical patterns of certain autoimmune diseases that manifest first at this age.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0563ef578a93287723b527d71ee71eca https://doi.org/10.1134/s2079057020040153 Zobrazit plný text záznamu Full text from SpringerLink