Analytical Standards Purity Determination Using Quantitative Nuclear Magnetic Resonance
| Autor: | Naoki Sugimoto, Toru Miura, Katsuo Asakura, Takako Suematsu, Kevin K. Millis, Yuko Yamada |
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| Rok vydání: | 2017 |
| Předmět: |
food.ingredient
Materials science Quantitative nmr 010405 organic chemistry Food additive Rosmarinic acid 010401 analytical chemistry Crude drug 01 natural sciences Magnolol 0104 chemical sciences chemistry.chemical_compound Certified reference materials food Japanese Pharmacopoeia Nuclear magnetic resonance chemistry Magnoflorine |
| Zdroj: | New Horizons of Process Chemistry ISBN: 9789811034206 |
| DOI: | 10.1007/978-981-10-3421-3_20 |
| Popis: | Quantitative nuclear magnetic resonance (qNMR) with Internal Standard named as AQARI (Accurate QuAntitative NMR with Internal standard material) has been adopted by the Japanese Pharmacopoeia and the Japanese Standard of Food Additives as an official analytical method because of reliability and efficiency. We have developed Certified Reference Material (CRM) suitable for AQARI and utilitized AQARI with developed CRM to characterize analytical standards and certified reference materials (CRMs) for use in developing qNMR and chromatographic calibration standards. AQARI was used to determine the chemical purity of analytical standards for more than 500 compounds, including the following seven Japanese Pharmacopoeia crude drug products: magnolol, geniposide, paeonol, magnoflorine Iodide, saikosaponin b2, (E)-cinnamic acid and rosmarinic acid. |
| Databáze: | OpenAIRE |
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