Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection
| Autor: | Yuh Fukuda, Seiichiro Higo, Yukinari Masuda, Emiko Fujita, Yusuke Kajimoto, Tomohiro Kaneko, Akiko Mii, Yasuhiko Iino, Chikara Ishihara, Akira Shimizu, Shinya Nagasaka, Go Kanzaki, Yasuo Katayama |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.diagnostic_test
Endocapillary proliferative glomerulonephritis biology Parvovirus business.industry Glomerulonephritis Immunofluorescence medicine.disease biology.organism_classification Immunoglobulin G Pathology and Forensic Medicine Pathogenesis Nephritic syndrome Immunology medicine biology.protein Renal biopsy business |
| Zdroj: | Human Pathology. 43:2326-2333 |
| ISSN: | 0046-8177 |
| Popis: | Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is a recently described disease entity, characterized by nonorganized electron-dense deposits in glomeruli and immunofluorescence findings indicating monoclonal immunoglobulin G deposits. The pathogenesis of many cases of proliferative glomerulonephritis with monoclonal immunoglobulin G deposits remains unknown. We herein report 2 patients with parvovirus B19 infection who developed acute nephritic syndrome with hypocomplementemia (patient 1) or persistent proteinuria and congestive heart failure (patient 2); however, neither patient had detectable levels of serum monoclonal immunoglobulin G. Renal biopsy in both patients showed diffuse endocapillary proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits, and electron microscopy showed nonorganized electron-dense deposits mainly in the subendothelial and mesangial areas. Clinical symptoms, abnormal laboratory findings, and urinary abnormalities recovered spontaneously in both cases within 4 weeks. Our 2 cases may be the first reported patients with proliferative glomerulonephritis with monoclonal immunoglobulin G deposits possibly associated with parvovirus B19 infection. Virus infection-associated immune disorders could be implicated in the pathogenesis of proliferative glomerulonephritis with monoclonal immunoglobulin G deposits. |
| Databáze: | OpenAIRE |
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