Synthesis of novel spiro-pyrazole and spiro-isoxazoline derivatives of 9α- and 9β-hydroxyparthenolide

Autor:	Mohamed Moumou, Abdellah Hannioui, Mohamed Akssira, Mohamed Saadi, Fatima Outahar, El Mostapha Rakib, Lahcen El Ammari
Rok vydání:	2020
Předmět:	biology 010405 organic chemistry Stereochemistry Organic Chemistry Pyrazole 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Anvillea Drug Discovery
Zdroj:	Tetrahedron Letters. 61:152409
ISSN:	0040-4039
Popis:	A series of novel spiropyrazoles and spiroisoxazolines was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. The structures and stereochemistry of the cycloadducts were fully established by spectroscopic methods including X-ray diffraction data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::054b8f1282f77889e47643117b789d0a https://doi.org/10.1016/j.tetlet.2020.152409 Zobrazit plný text záznamu Full Text from ScienceDirect