The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer

Autor:	Heng Luo, Dalong Song, Jianxin Hu, Zhaolin Sun, Guangheng Luo, Youlin Kuang, Shuxiong Xu, Yuangao Xu, Jianguo Zhu
Rok vydání:	2019
Předmět:	0301 basic medicine Cancer Research Gene knockdown NF-κB General Medicine Biology urologic and male genital diseases medicine.disease_cause medicine.disease 03 medical and health sciences chemistry.chemical_compound Prostate cancer 030104 developmental biology 0302 clinical medicine Oncology chemistry 030220 oncology & carcinogenesis medicine Cancer research Phosphorylation Signal transduction Carcinogenesis Protein kinase B PI3K/AKT/mTOR pathway
Zdroj:	Cancer Investigation. 37:199-208
ISSN:	1532-4192 0735-7907
Popis:	Prostate cancer (PCa) is the most common malignant tumor for men. But the mechanism is unclear. EIF3C was shown to be overexpressed in PCa tissues and cell lines. EIF3C overexpression was correlated to age and tumor stage in PCa patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Additionally, the phosphorylation level of PI3K and Akt was downregulated while total NF-κB and Myc decreased after EIF3C knockdown. But the expression of IκB increased reversely. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-κB signaling pathway in PC3 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0546e031f555835fbce66c6ad386a503 https://doi.org/10.1080/07357907.2019.1618322 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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