The impact of some parameters on linkage analysis of Alzheimer's disease

Autor:	A. S. Chung, Gary A. Chase, Nancy E. Maestri, F. W. Lung, DA Meyers, Jianfeng Xu, Eugene W. Taylor
Rok vydání:	1993
Předmět:	Genetics Linkage (software) Phenocopy Epidemiology Genetic heterogeneity nutritional and metabolic diseases Disease Biology medicine.disease Penetrance Degenerative disease Genetic linkage medicine Alzheimer's disease Genetics (clinical)
Zdroj:	Genetic Epidemiology. 10:407-412
ISSN:	0741-0395
DOI:	10.1002/gepi.1370100613
Popis:	The two-point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age-dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0545ccd59f6ec2c4630d4b58c5b67acb https://doi.org/10.1002/gepi.1370100613 Zobrazit plný text záznamu Plný text