Spermatogenesis in Azoospermic, Formerly Cryptorchid Men
Autor: | R Romani, Giancarlo Di Coscio, Vincenzo Nardini, Angelo Carpi, G. Fabrizio Menchini Fabris, Antonella Chiechi |
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Rok vydání: | 2002 |
Předmět: |
Gynecology
Azoospermia endocrine system medicine.medical_specialty Histology urogenital system business.industry Urology General Medicine Unilateral cryptorchidism medicine.disease Sertoli cell Pathology and Forensic Medicine medicine.anatomical_structure Oligospermia Cytopathology Predictive value of tests Cytology medicine business Spermatogenesis |
Zdroj: | Acta Cytologica. 46:848-854 |
ISSN: | 1938-2650 0001-5547 |
Popis: | OBJECTIVE: To assess the use of testicular needle aspiration techniques to evaluate fertility potential in azoospermic, formerly cryptorchid men. STUDY DESIGN: Fifteen consecutive adult azoospermic, formerly cryptorchid patients (eight unilateral and seven bilateral) were examined by needle aspiration techniques, fine (FNA) and large needle (LNAB) testicular aspiration biopsy, for cytologic and histologic analysis. Five of the 15 subsequently underwent surgical biopsy for attempted assisted fertilization. RESULTS: Spermatozoa or spermatids were detected by FNA cytology or LNAB histology in one or both testicles in 87.5% of the unilateral and 28. 6% of the bilaterally affected, formerly cryptorchid patients (P = .041, Fisher's exact test). The addition of LNAB to FNA identified spermatids in one patient with unilateral cryptorchidism and only Sertoli cells on FNA cytology. Furthermore, LNAB differentiated testicles with the cytologic finding of only Sertoli cells into those with or without diffuse fibrosis. In the five patients in whom assisted fertilization was attempted, the needle aspiration techniques predicted the presence or absence of spermatozoa in the subsequent surgical biopsy. CONCLUSION: The two needle aspiration techniques can be used to assess the fertility potential of azoospermic, formerly cryptorchid men and to select patients for assisted fertilization. |
Databáze: | OpenAIRE |
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