Serogroup B meningococcal disease in the Norwegian armed forces. What can we learn from an inconclusive vaccine protection trial?
| Autor: | E.A. Hø, P.G. Djupesland, J.K. Grønnesby, R. Mundal, G. Bjune |
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| Rok vydání: | 1997 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Immunogenicity Neisseria meningitidis Public Health Environmental and Occupational Health Booster dose medicine.disease_cause Meningococcal disease medicine.disease Vaccination Military personnel Carriage Immunization Immunology medicine business |
| Zdroj: | The European Journal of Public Health. 7:261-266 |
| ISSN: | 1464-360X 1101-1262 |
| Popis: | Military recruits serving in the armed forces were severely affected during the latest serogroup B meningococcal epidemic in Norway. The risk of developing systemic meningococcal disease (SMD) proved highest during the first 12 weeks of service. A double-blind, placebo-controlled protection trial with a meningococcal outer membrane vesicle vaccine took place between 1988 and 1991, but the number of proven SMD cases was too low to allow for any conclusions. However, the results of a parallel efficacy study of the same vaccine among students in secondary school, cross-society examinations for asymptomatic throat carriage of meningococci and recent immunogenicity studies after two- and three-dose vaccination schedules, suggest that a basic immunization of young teenagers followed by a booster injection at enrolment would contribute significantly to preventing SMD in the armed forces. |
| Databáze: | OpenAIRE |
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