Selective Synthesis of Indoles by Cobalt(III)-Catalyzed C–H/N–O Functionalization with Nitrones
| Autor: | Lutz Ackermann, María J. González, Marc Moselage, Hui Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Indole test
Annulation 010405 organic chemistry Substrate (chemistry) chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Surface modification Organic chemistry Carboxylate Cobalt |
| Zdroj: | ACS Catalysis. 6:2705-2709 |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.5b02937 |
| Popis: | The redox-neutral annulation of alkynes by differently decorated nitrones set the stage for a step-economical access to indoles with ample substrate scope. The redox-neutral C–H/N–O functionalization process proceeded through kinetically relevant C–H activation by carboxylate assistance, and displayed an excellent site- and regio-selectivity with unsymmetrical nitrones and alkynes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|