| Popis: |
s S57 the GFP-marked cells were confined strictly to ischemic areas and represented approximately 10 % of total cellularity and coexpressed collagen type IV and troponin T or myosin heavy chain, characteristic ofMSCs and cardiomyocytes, respectively, and were CD45(-). Despite the absence of donor cells in the infarcted myocardium21 days after infusion,mice that have receivedMSCs alone compared to MSCs transfected with an S100A6 siRNA or saline alone showed a 6-fold increase in S100A6 in peri-infarcted myocardium, attenuated myocyte hypertrophy, decreased fibrosis and apoptosis and preservation of cardiac function. CONCLUSION: The secretion of S100A6 by infused BM-MSCs may contribute in limiting adverse left ventricular remodeling post-MI. 005 A CCN1-COLLAGEN BIOMATERIAL FOR THE TREATMENT OF MYOCARDIAL INFARCTION B McNeill, B Vulesevic, N Blackburn, M Ruel, EJ Suuronen |
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