Gastric Bypass Increases Circulating Bile Acids and Activates Hepatic Farnesoid X Receptor (FXR) but Requires Intact Peroxisome Proliferator Activator Receptor Alpha (PPARα) Signaling to Significantly Reduce Liver Fat Content
| Autor: | Matthew G. Browning, Guilherme M. Campos, Huiping Zhou, Martin J. Mangino, Guilherme S. Mazzini, Elvin T. Price, Jilin Wu, Luke G. Wolfe, Jad Khoraki |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bile acid medicine.drug_class business.industry Fatty liver Gastroenterology Antagonist nutritional and metabolic diseases Alpha (ethology) medicine.disease 03 medical and health sciences 0302 clinical medicine Endocrinology Weight loss 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Surgery Farnesoid X receptor medicine.symptom Steatosis business Receptor |
| Zdroj: | Journal of Gastrointestinal Surgery. 25:871-879 |
| ISSN: | 1873-4626 1091-255X |
| Popis: | We interrogate effects of gastric bypass (RYGB), compared with a low-calorie diet, on bile acid (BA), liver fat, and FXR, PPARα, and targets in rats with obesity and non-alcoholic fatty liver disease (NAFLD). Male Wistar rats received a high-fat diet (obese/NAFLD, n=24) or standard chow (lean, n=8) for 12 weeks. Obese/NAFLD rats had RYGB (n=11), sham operation pair-fed to RYGB (pair-fed sham, n=8), or sham operation (sham, n=5). Lean rats had sham operation (lean sham, n=8). Post-operatively, five RYGB rats received PPARα antagonist GW6417. Sacrifice occurred at 7 weeks. We measured weight changes, fasting total plasma BA, and liver % steatosis, triglycerides, and mRNA expression of the nuclear receptors FXR, PPARα, and their targets SHP and CPT-I. At sacrifice, obese sham was heavier (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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