METABOLIC RECONSTRUCTION FOR DEVELOPING A TISSUE-SPECIFIC MODEL FOR CATTLE GLYCOLYSIS USING COBRA
| Autor: | Hye Sun Park, Do-Gyun Kim, Sung-Won Seo, Wang-Hee Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Ecology Applied Mathematics Mammary gland Cobra General Medicine Biology Agricultural and Biological Sciences (miscellaneous) 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Biochemistry Gene expression medicine Tissue specific Glycolysis computer computer.programming_language |
| Zdroj: | Journal of Biological Systems. 25:231-246 |
| ISSN: | 1793-6470 0218-3390 |
| Popis: | This study aims at developing a tissue-specific model for glycolysis in bovine mammary gland epithelial cells by incorporating gene expression data into metabolic reactions. Two types of data sets were embedded in the COnstraint-Based Reconstruction Analysis (COBRA) toolbox: metabolic reactions that overlay bovine genetic information into human glycolysis data from a public database and gene expression data of cattle acquired from lab experiments. As a result, we successfully generated a tissue-specific model of bovine glycolysis in bovine mammary gland epithelial cells, providing information on expression of metabolic pathways and gene annotations still required for curation. |
| Databáze: | OpenAIRE |
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