Survivin in Multiple Myeloma: Prognostic and Therapeutic Implications

Autor:	Bernard Klein, Verena Wagner, Tobias Meißner, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Ludmila Weitz, Marc S. Raab, Alwin Krämer, Jean-François Rossi, Thierry Rème
Rok vydání:	2011
Předmět:	Pathology medicine.medical_specialty Stromal cell Immunology Cell Cell Biology Hematology Biology medicine.disease Biochemistry medicine.anatomical_structure Apoptosis Survivin medicine Cancer research Bone marrow Mitosis Multiple myeloma Cytokinesis
Zdroj:	Blood. 118:137-137
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v118.21.137.137
Popis:	Abstract 137 The IAP (inhibitor-of-apoptosis) family member, survivin, is one of the most significantly over-expressed genes in malignant cells. Survivin has been reported to inhibit apoptosis and regulate mitosis as well as cytokinesis. We therefore first determined the expression of survivin in CD138-purified multiple myeloma (MM) cells from previously untreated patients at our centers' trial group (TG) (n=246) and the UAMS Arkansas (n=345) validation group (VG). Using the PANP algorithm, survivin is aberrantly expressed in 27% (TG) of MM cell samples. It is not expressed in normal bone marrow plasma cell samples (n=7) while expression increases significantly from MM stage I-III (P Disclosures: No relevant conflicts of interest to declare.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05363f14eae29f2e55bb906c548e820b https://doi.org/10.1182/blood.v118.21.137.137 Zobrazit plný text záznamu