Synthesis and spectroscopic studies of furan-bridged polyazamacrocycles through 15,16-bis((prop-2-ynylamino)methyl)labdatriene transformations
| Autor: | Yurii V. Kharitonov, Elvira E. Shults, Olga I. Brusentzeva, Dmitry S. Fadeev |
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| Rok vydání: | 2019 |
| Předmět: |
Sodium ascorbate
010405 organic chemistry Chemistry Metal ions in aqueous solution General Chemistry Optically active 010402 general chemistry Condensed Matter Physics 01 natural sciences Chloride Medicinal chemistry Cycloaddition Terpenoid 0104 chemical sciences chemistry.chemical_compound Furan medicine Methylene Food Science medicine.drug |
| Zdroj: | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 96:245-250 |
| ISSN: | 1573-1111 1388-3127 |
| Popis: | The design and the preparation of a small library of optically active polyazamacrocyclic compounds with a furan bridge, connected by (4-(methylaminomethyl)-1,2,3-triazole) rings with methylene, ethyloxyethyl or ethylethoxyethyl units from natural labdanoid lambertianic acid is reported. The synthesis of the key 15,16-bis((tert-butoxycarbonyl(prop-2-ynyl)amino)methyl)labda-8(9),13,15-labdatriene from the plant diterpenoid lambertianic acid is also described. CuAAC reaction of this compounds with various diazides in the presence of Cu(II)/sodium ascorbate in methylene chloride/water reaction medium led to the mentioned chiral macrocyclic compounds with a furan bridge binding Zn2+ ions in solution. |
| Databáze: | OpenAIRE |
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