Tissue Engineering von Skelettmuskelgewebe - Stand und Perspektiven

Autor:	Anja M. Boos, D. Klumpp, Justus P. Beier, Ulrich Kneser, Raymund E. Horch, F Bitto
Rok vydání:	2010
Předmět:	Muscle tissue Future perspective business.industry Skeletal muscle Anatomy medicine.anatomical_structure Tissue engineering medicine Skeletal Muscle Tissue Myocyte Orthopedics and Sports Medicine Surgery Muscle transfer Contracture medicine.symptom business Neuroscience
Zdroj:	Handchirurgie · Mikrochirurgie · Plastische Chirurgie. 42:354-359
ISSN:	1439-3980 0722-1819
DOI:	10.1055/s-0030-1261888
Popis:	Tissue engineering of skeletal muscle could have great advantages in every clinical setting in need of neurovascular muscle transfer, e. g., facial palsy or Volkmann's contracture. There are 2 great obstacles for the clinical application of engineered muscle tissue at the moment: firstly, finding a three-dimensional matrix that matches the demands concerning biocompatibility, stability and elasticity; secondly, the insufficient differentiation of implanted myoblasts, since myoblast differentiation in vivo is barely controllable and subject to a variety of influences. Furthermore axial vascularisation and neurotisation of such tissue-engineered skeletal muscle constructs play a pivotal role for any later application. An overview of the current status of skeletal muscle tissue engineering technologies and concepts for future perspective in this emerging field is presented in this article.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::052756c7fc9fe29266c6abe5fb84581f https://doi.org/10.1055/s-0030-1261888 Zobrazit plný text záznamu