| Popis: |
Recent studies have provided substantial knowledge regarding the genetic and immunological landscape for penile squamous cell carcinoma (PSCC). This new information paved the way for exploring new therapies that might be of use. This chapter will tackle specific techniques involving targeted, immune, and viral therapies. In targeted therapy, dacomitinib, PARP inhibitors, and NOTCH1 targeted therapies may hold potential promise. As for immune therapy, immune checkpoint blockade (ICB) combination therapy and PD-L1 expression studies showed promising results with a good response rate. Finally, HPV targeting studies offered exciting results that could be of use in the management of PSCC patients. |
