| Autor: |
Fiona MacDougall, Howard N.E. Stevens, Lee Ann Hodges |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Hydrophilic Matrix Tablets for Oral Controlled Release ISBN: 9781493915187 |
| DOI: |
10.1007/978-1-4939-1519-4_12 |
| Popis: |
The complexity of the local environment of the gastrointestinal tract presents a significant challenge for achieving reliable performance of hydrophilic matrix oral dosages, and designing robustness into the formulation is key to achieving reproducible behaviour in vivo. This chapter outlines the physiological variables which must be taken into account during the development phase, and describes the different in vitro approaches used in attempts to simulate the interactions that may occur between hydrophilic matrix dosage forms and the GI environment in vivo. A series of in vivo case studies describes methods for assessing the clinical performance of hydrophilic matrix dosages using imaging techniques, and gives examples where such tools have been used to elucidate dosage form–food interactions and dosage form gastrointestinal tract interactions. Key findings are summarised from these in vivo case studies, ranging from identification of food effects to assessment of matrix robustness. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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