Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

Autor:	Johann H. Sattler, Wolfgang Kroutil, Michael Fuchs, Katharina Tauber, Kurt Faber, Jan Pfeffer, Horst Lechner
Rok vydání:	2012
Předmět:	Antifungal Naftifine chemistry.chemical_classification Aqueous medium medicine.drug_class Transamination General Chemical Engineering General Chemistry chemistry.chemical_compound chemistry Alcohol oxidation Galactose oxidase medicine Organic chemistry Amination
Zdroj:	RSC Advances. 2:6262
ISSN:	2046-2069
Popis:	The amination of benzylic and cinnamic alcohols was achieved via a biocatalytic, one-pot oxidation–transamination cascade in aqueous medium at physiological conditions. Alcohol oxidation by galactose oxidase at the expense of O2 furnished the corresponding aldehydes, which were aminated using ω-transaminases in situ. The applicability of this method was demonstrated by a short synthesis of the antifungal agent naftifine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::05185888252a076c63a77a147c9c7633 https://doi.org/10.1039/c2ra20800h Zobrazit plný text záznamu