Synthesis of tetranor-PGE1: A urinary metabolite of prostaglandins E1 and E2
| Autor: | Somnath Jana, Gary A. Sulikowski, Alexander Allweil, Jennifer R Kimbrough, Kwangho Kim, Ginger L. Milne, John A. Oates |
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| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Metabolite Urinary system Organic Chemistry Late stage Total synthesis Inflammation 010402 general chemistry 01 natural sciences Biochemistry Chemical synthesis 0104 chemical sciences chemistry.chemical_compound Human disease chemistry Drug Discovery medicine lipids (amino acids peptides and proteins) Prostaglandin E2 medicine.symptom medicine.drug |
| Zdroj: | Tetrahedron Letters. 61:151922 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2020.151922 |
| Popis: | Prostaglandin E2 is produced in response to inflammation, often associated with human disease. As prostaglandins are rapidly metabolized, quantification of end urinary metabolites depend on chemical synthesis of isotopically labeled standards to support metabolite quantification. A concise synthesis of tetranor-PGE1 is described including a late stage incorporation of an isotopically labeled side-chain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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