Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

Autor:	Anne E. Mohan, Aaron S. Cote, Eric Khong, Keith A. Mattern, Michael Whittington, Kevin M. Maloney, Eric B. Sirota, Yee Swan Ang, Michael DiBenedetto, Anthony Diaz-Santana, Richard Desmond, Ivan H. Lee, Beata Tao, Muhammad Sofian Bin Asi Sihombing, Christopher Pridgen, Glenn Spencer, Hsieh Yao D. Chang, Kevin M. Sirk, Hong Ren, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, Cuixian Yang
Rok vydání:	2021
Předmět:	Active ingredient Phase map 010405 organic chemistry business.industry Chemistry Scientific method Organic Chemistry Physical and Theoretical Chemistry 010402 general chemistry Process engineering business 01 natural sciences 0104 chemical sciences
Zdroj:	Organic Process Research & Development. 25:541-551
ISSN:	1520-586X 1083-6160
Popis:	The final chemical transformation and isolation in the synthesis of an active pharmaceutical ingredient (API), referred to as the Pure Step, is often chemically simple but scientifically, operation...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::050d565e3d00180c82c678ebb7b2a798 https://doi.org/10.1021/acs.oprd.0c00488 Zobrazit plný text záznamu