Comparative Assessment of the Proteolytic Stability and Impact of Poly-Arginine Peptides R18 and R18D on Infarct Growth and Penumbral Tissue Preservation Following Middle Cerebral Artery Occlusion in the Sprague Dawley Rat
| Autor: | Kirk W. Feindel, Diego Milani, Vince W. Clark, Bruno P. Meloni, Neville W. Knuckey, Adam B. Edwards, Ryan S. Anderton, Michael Bynevelt, David Blacker |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
business.industry Plasmin medicine.medical_treatment Penumbra Proteolytic enzymes General Medicine Thrombolysis Pharmacology medicine.disease Biochemistry Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine medicine business Saline Perfusion Stroke 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurochemical Research. 46:1166-1176 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-021-03251-y |
| Popis: | Poly-arginine peptides R18 and R18D have previously been demonstrated to be neuroprotective in ischaemic stroke models. Here we examined the proteolytic stability and efficacy of R18 and R18D in reducing infarct core growth and preserving the ischaemic penumbra following middle cerebral artery occlusion (MCAO) in the Sprague Dawley rat. R18 (300 or 1000 nmol/kg), R18D (300 nmol/kg) or saline were administered intravenously 10 min after MCAO induced using a filament. Serial perfusion and diffusion-weighted MRI imaging was performed to measure changes in the infarct core and penumbra from time points between 45- and 225-min post-occlusion. Repeated measures analyses of infarct growth and penumbral tissue size were evaluated using generalised linear mixed models (GLMMs). R18D (300 nmol/kg) was most effective in slowing infarct core growth (46.8 mm3 reduction; p |
| Databáze: | OpenAIRE |
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