The two highly immunogenic antigens of Brucella: lipopolysaccharide (LPS) and outer membrane proteins (OMPs)
| Autor: | Hannah Leah Tadeja Simborio, Suk Kim, Wongi Min, Huynh Tan Hop, Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy |
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| Rok vydání: | 2015 |
| Předmět: |
biology
Lipopolysaccharide Chemistry Virulence chemical and pharmacologic phenomena Brucella bacterial infections and mycoses Antimicrobial biology.organism_classification complex mixtures Microbiology chemistry.chemical_compound Antigen lipids (amino acids peptides and proteins) Bacterial outer membrane Function (biology) Bacteria |
| Zdroj: | Journal of the Preventive Veterinary Medicine. 39:198-206 |
| ISSN: | 2287-8009 2287-7991 |
| Popis: | The bacterial lipopolysaccharide (LPS) mainly contributes to the structural integrity, survival and protection barrier against harsh environments. Therefore, the early stages in LPS or lipid A biosynthesis are attractive targets in the identification and development of inhibitors which would be effective against infections caused by Gram-negative bacteria. The bacterial outer membrane proteins (OMPs) meanwhile function as maintenance for structure, adhesion to other cells and substances, as well as development of resistance to antimicrobials. The LPS and LPS-related molecules, and OMPs are important immunogenic components of several important pathogens including Brucella, which have been extensively used in immunological studies and in the diagnosis of diseases. Here we review the importance, structure, functions and immunogenic aspects of LPS and OMPs particularly of Brucella which can be targeted for the prevention and diagnosis of brucellosis. |
| Databáze: | OpenAIRE |
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