BMS-747158-02: A novel PET myocardial perfusion imaging agent
| Autor: | Ming Yu, David S. Casebier, Simon P. Robinson, Mikhail Kagan, Mary Guaraldi, Mahesh Mistry, Jennifer McDonald, Radeke Heike S, Kenneth Drew, Michael Azure, Ajay Purohit |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Biodistribution
Lung medicine.diagnostic_test business.industry chemistry.chemical_element Blood flow Single-photon emission computed tomography Myocardial perfusion imaging medicine.anatomical_structure chemistry Positron emission tomography medicine Thallium Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine Nuclear medicine business Perfusion |
| Zdroj: | Journal of Nuclear Cardiology. 14:789-798 |
| ISSN: | 1071-3581 |
| DOI: | 10.1016/j.nuclcard.2007.07.008 |
| Popis: | Background BMS-747158-02 is a fluorine 18–labeled pyridaben derivative designed as a new myocardial perfusion imaging agent for use with positron emission tomography (PET). This study evaluated BMS-747158-02 in animal models of cardiac perfusion and compared it with established single photon emission computed tomography agents. Methods and Results In a rat biodistribution study, BMS-747158-02 (15 μCi) had substantially higher myocardial uptake than technetium 99m sestamibi (100 μCi) at 15 minutes (3.5% ± 0.3% %ID/g vs 1.9% ± 0.1% %ID/g) and 120 minutes (3.2% ± 0.4% of injected dose per gram vs 1.8% ± 0.0% of injected dose per gram) after intravenous administration. Uptake ratios of heart to lung and liver at 60 minutes were also higher for BMS-747158-02 (12.7 ± 1.4 and 3.7 ± 0.2, respectively) than Tc-99m sestamibi (5.9 ± 0.5 and 2.4 ± 0.4, respectively). In an isolated rabbit heart model at flow rates of 1.66 to 5.06 mL · min−1 · g−1 wet left ventricular weight, the net BMS-747158-02 heart uptake increased proportionally (0.93 ± 0.15 to 2.44 ± 0.40 mL · min−1 · g−1) and to a greater extent than that of thallium 201 (0.76 ± 0.02 to 1.11 ± 0.02 mL · min−1 · g−1) or Tc-99m sestamibi (0.49 ± 0.03 to 0.77 ± 0.08 mL · min−1 · g−1). PET imaging with BMS-747158-02 showed a clear and sustained cardiac uptake in rats, rabbits, and nonhuman primates with minimal lung interference and rapid liver clearance. Myocardial perfusion deficit zones created by either permanent left coronary ligation or reperfusion after ligation in rats were both clearly identified on PET cardiac images of BMS-747158-02 and had good agreement with in vitro histology. Conclusions BMS-747158-02 exhibited high and sustained cardiac uptake that was proportional to blood flow, and it represents a new class of PET myocardial perfusion imaging agent. |
| Databáze: | OpenAIRE |
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