Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
| Autor: | Linh Nhat Nguyen, Liem Quang Nguyen, Nagendra Kumar Kaushik, Pradeep Bhartiya, Sintayehu Kebede Gurmessa, Hwa-Jung Kim, Neha Kaushik, Eun Ha Choi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
health care facilities manpower and services General Chemical Engineering medicine.medical_treatment media_common.quotation_subject education Autophagy technology industry and agriculture Damage-associated molecular pattern 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Immune system Cancer immunotherapy Immunity Cancer cell medicine Cancer research Immunogenic cell death 0210 nano-technology Internalization media_common |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 100:99-111 |
| ISSN: | 1226-086X |
| DOI: | 10.1016/j.jiec.2021.05.035 |
| Popis: | The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on the use of polydopamine-coated gold nanoparticles (Au@PDA NPs) that showed excellent selectivity towards cancer cells. The Au@PDA NPs were prepared by a plasma synthesis method with a short reaction time and minimize the use of chemicals. Prominently, Au@PDA NPs not only exhibited high cellular internalization but also stimulated immunogenic cell death (ICD) in aggressive breast carcinoma cells. Moreover, it was observed that damage-associated molecular patterns (DAMPs) were released by damaged cells together with the autophagy process after Au@PDA NPs exposure, which acted as endogenous danger signals to regulate the consequent immune response. This study highlights the novel mechanism of Au@PDA NPs-triggered anti-tumor immunity against immunosuppressive cancers, demonstrated the potential of the Au@PDA NPs for cancer immunotherapy. |
| Databáze: | OpenAIRE |
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