Effect of Alpha Lipoic Acid on Oxidative Stress and Chronic Inflammation Markers in Diabetic Older Adults

Autor: Mirna Ruiz-Ramos, Beatriz Isabel García-Martínez, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez
Rok vydání: 2017
Předmět:
Zdroj: Free Radical Biology and Medicine. 112:130
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2017.10.196
Popis: Background Alpha lipoic acid (ALA) is a compound with antioxidant and anti-inflammatory properties. Recent studies have suggested that taking ALA supplements could be an effective way of treating diabetes and its complications, although its use in diabetic older adults is still controversial. Aim To determine the effect of intake of ALA on oxidative stress and chronic inflammation markers in diabetic older adults. Design A randomized, double-blind controlled trial was carried out. We evaluated 108 older adults diabetics without hepatic or renal damage. They were divided into 3 groups: i) treatment group (TG), n= 42 subjects, intake 600 mg/day of ALA, ii) placebo group (PG), n= 38 subjects, intake 600 mg/day of placebo and iii) control group (CG), n= 28 subjects, without intake of ALA or placebo. We measured before and after of six months of treatment, the plasmatic levels of isoprostane by ELISA, SOD and GPx by spectrophotometry, and TNF-α, IL-1β, IL-6 by flow cytometry. Differences within and between groups were compared by repeated measures ANOVA test. Outcomes: After 6 months the serum isoprostane levels the TG and PG had a decreased statistically significance in comparison to CG, however it was not observed significantly differences between both (TG, basal 100±5 vs. post 57±3; PG, basal 106±7 vs. post 77±5; CG, basal 94±9 vs. six months 107±10 pg/mL, p Conclusion Our findings suggest that the intake of 600mg/day of ALA has an effect antioxidant and anti-inflammatory similar to placebo.
Databáze: OpenAIRE
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