CTAB–tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] interaction: a tool for predicting organotin(IV) complex–cell membrane interaction parameters
| Autor: | Shaista Sabir, Asad Muhammad Khan, Saqib Ali, Farooq Ali Shah |
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| Rok vydání: | 2015 |
| Předmět: |
Denticity
Polymers and Plastics biology 010405 organic chemistry Chemistry Ligand 010402 general chemistry 01 natural sciences Micelle 0104 chemical sciences Colloid and Surface Chemistry Pulmonary surfactant Critical micelle concentration Polymer chemistry Materials Chemistry biology.protein Molecule Organic chemistry Physical and Theoretical Chemistry Fourier transform infrared spectroscopy Organic anion |
| Zdroj: | Colloid and Polymer Science. 294:87-94 |
| ISSN: | 1435-1536 0303-402X |
| DOI: | 10.1007/s00396-015-3738-x |
| Popis: | This study attempts to explain the bioavailability, permeability, and interaction parameters of organotin(IV) derivatives with the cell membrane. For this purpose, tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] was synthesized and characterized by elemental analysis and spectroscopic methods (Fourier transform infrared spectroscopy (FT-IR), 1H, 13C, 119Sn NMR). The organic anion was found to act as monodentate O-bound ligand in solution. Cationic surfactant cetyl N,N,N-trimethylammoniumbromide (CTAB) was used to study the interactions of the organotin(IV) complex with positively charged molecules of the surfactant acting as a model cell membrane. The thermodynamic parameters of complex–CTAB interaction concluded that the complex is located in the peripheral region of CTAB micelles. The redshifts in the UV spectra of the complex confirmed its solubilization into micelles. The two carbonyl oxygen atoms were found to be binding sites of the complex with CTAB. |
| Databáze: | OpenAIRE |
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