Iatrogenic phenytoin toxicity – Newer lessons learnt
| Autor: | Anjishnujit Bandyopadhyay, Vikas Saini, Vighnesh Ashok, Balaji Kannamani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Phenytoin
Drug Pediatrics medicine.medical_specialty PHENYTOIN TOXICITY business.industry media_common.quotation_subject digestive oral and skin physiology Encephalopathy General Medicine Status epilepticus medicine.disease nervous system diseases stomatognathic diseases Therapeutic index Seizure Disorders otorhinolaryngologic diseases Seizure control Medicine heterocyclic compounds medicine.symptom business medicine.drug media_common |
| Zdroj: | Saudi Critical Care Journal. 5:33 |
| ISSN: | 2543-1854 |
| DOI: | 10.4103/sccj.sccj_33_20 |
| Popis: | Phenytoin is a widely prescribed anti-epileptic drug (AED), but overdoses are common given its narrow therapeutic index. A 24-year-old male, a previously diagnosed case of seizure disorder on multiple AEDs, including phenytoin presented with breakthrough seizures to the medical emergency. The subsequent medical management of this patient led to an inadvertent iatrogenic overdose of phenytoin resulting in encephalopathy in this patient. Given our experience in this patient, we suggest using a newer class of AED for seizure control in a patient already on phenytoin, particularly if immediate therapeutic plasma phenytoin level monitoring is not readily available. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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