| Autor: |
Lin Ao, Kun Liu, Guizhong Hou, Jinyi Liu, Qing Chen, Huatao Chen, Niya Zhou, Xiaogang Wang, Xi Zhang, Huan Yang, Fei Han, Fuquan Shi, Jia Cao, Chang Liu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3482809 |
| Popis: |
Social jetlag (SJ), discrepancy from inner clock for work and non-work-related reasons, is prevalent worldwide and has been associated with decreased fertility in women, but not in men. In the current study, we firstly extracted the national rate of rotating shift work (RSW) in men of reproductive age (15-49 years) from 35 European countries from the European Working Conditions Survey. Regression analysis revealed an inverse correlation between RSW and the national fertility rate (as reported by the World Bank; P < 0.001). For every 10% increase in RSW rate, fertility rate decreased by 0.114 (equivalent to 11.4 fewer births per 100 women). Then we compared 16 semen/reproductive-hormone parameters of RSW workers against day workers in 1346 reproductive-age Chinese men. RSW was associated with 1.26 (95%CI 1.05-1.52) fold risk of low sperm count. The SJ-sperm correlation was also observed in a cohort of 796 unemployed reproductive-age Chinese undergraduates: each hour non-work-related SJ between school days and days off was associated with 1.16 (95%CI 1.02-1.31) fold risk, and sperm count increased during follow up in men who reduced SJ after baseline. At last, a mouse model subjected to photoperiod shifting was established to simulate SJ and the related sperm decrease. Apoptosis analysis suggested the damage originated in spermatogenic cells in seminiferous tubules. Differentially expressed gene analysis showed that photoperiod shifting down-regulated marker genes of post-spermatocyte stage cells. The most enriched functional pathway was homologous recombination, which happened in spermatocytes during meiosis. Our study suggests that SJ is associated with male reproductive damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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