Antibacterial and antifungal potential of Ga-bioactive glass and Ga-bioactive glass/polymeric hydrogel composites
| Autor: | L. M. Placek, Anthony W. Wren, T. J. Keenan, M. M. Hall |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
food.ingredient Biomedical Engineering 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Microbiology law.invention Biomaterials food law medicine Agar Candida albicans Escherichia coli biology 021001 nanoscience & nanotechnology biology.organism_classification Corpus albicans 0104 chemical sciences Staphylococcus aureus Bioactive glass Self-healing hydrogels 0210 nano-technology Bacteria Nuclear chemistry |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 105:1102-1113 |
| ISSN: | 1552-4973 |
| DOI: | 10.1002/jbm.b.33655 |
| Popis: | A bioactive glass series (0.42SiO2 -0.10Na2 O-0.08CaO-(0.40 - x)ZnO-(x)Ga2 O3 ) was synthesized, and it is efficacy against the Gram (-ve) bacteria Escherichia coli (E. coli), the Gram (+ve) bacteria Staphylococcus aureus (S. aureus), and the fungus Candida albicans (C. albicans), were characterized through liquid broth analysis. The glass series was also seeded in CMC-Dex hydrogels at three different loadings (0.05, 0.10, and 0.25 m2 ), and the antibacterial and antifungal efficacies of the resulting composites were characterized using both liquid broth and agar diffusion analysis. Liquid broth analysis was conducted using liquid extracts, which for glass samples were obtained after incubation for up to 30 days in both ultrapure water and phosphate buffered saline (PBS), while glass-hydrogel extracts were obtained solely in PBS. Glass extracts (water) decreased C. albicans viability, while those obtained in PBS decreased the viability of both E. coli and C. albicans. Glass-hydrogel extracts exhibited slight inhibition of E. coli and C. albicans. However, none of the liquid extracts decreased S. aureus viability. Glass-hydrogel composites produced inhibition zones in all three microbial cultures, with the greatest efficacy against C. albicans. The results of this study suggest these materials have potential as bone void-filling materials which display antifungal, and possibly, antibacterial properties. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1102-1113, 2017. |
| Databáze: | OpenAIRE |
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