ChemInform Abstract: C-C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature

Autor:	Shenlin Huang, Guofu Zhong, Wendy Wen Yi Leong, Nicholas A. Isley, Bruce H. Lipshutz
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Addition reaction Halide chemistry.chemical_element General Medicine Zinc Catalysis chemistry.chemical_compound chemistry Reagent Polymer chemistry Enone Alkyl Conjugate
Zdroj:	ChemInform. 44
ISSN:	0931-7597
DOI:	10.1002/chin.201322040
Popis:	Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.
Databáze:	OpenAIRE
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